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For users who need the complete feature set, including the physical buttons and the C100S Manager application, the most reliable method is to run a virtual machine.

Despite its age, the C100S remains popular for its hardware quality: High-Fidelity Audio

While there is no official Polycom driver for Windows 10, hope is not entirely lost. Many users have reported success in getting the device partially functional. You may need to try a combination of the following solutions.