While not a direct confirmation, that joke acknowledges the broader phenomenon: the internet loves to confuse smart, funny redheads with adult actresses.
You might be thinking of a film involving Julianne Moore or Demi Moore , both of whom are prominent film actresses. samantha bee from a rodney moore film
If you are referring to: American actress, writer, and producer on the TBS parody news program Full Frontal with Samantha Bee. While not a direct confirmation, that joke acknowledges
Samantha Bee is a highly respected Canadian-American comedian, writer, and executive producer. While not a direct confirmation