As Hellboy navigates this complex web of evil, he is joined by his trusted allies, Liz Sherman (Naomi Novik) and Abe Sapien (Doug Jones). Together, they must prevent the Golden Army from destroying humanity and restore balance to the world. Along the way, Hellboy's character is further developed, exploring his struggles with his demonic heritage and his desire to be accepted as a human.

The film features an impressive cast, including: