While the Switch version is locked at lower frame rates, Yuzu allows players to increase the resolution (upscaling to 4K or higher) and potentially unlock framerates on modern hardware.

Note: AMD GPUs have historically struggled with Yuzu, but recent Vulkan updates have closed the gap significantly.

With a modern PC, Yuzu can run Borderlands 2 at higher frame rates (60+ FPS) and native resolutions (1080p, 4K) compared to the handheld's original settings.

Over time, the community found workarounds. Guides appeared for running the game at 1080p/60fps on PCs and optimizing it for high-end Android chips like the Snapdragon 870 or 888