| Role | Actor / Crew Member | |---------------|----------------------------| | Elisabeth Sparkle | Demi Moore | | Sue | Margaret Qualley | | Harvey | Dennis Quaid | | Fred | Edward Hamilton Clark | | Oliver | Gore Abrams | | Troy | Oscar Lesage | | Man at diner | Christian Erickson | | Male nurse | Robin Greer | | The Substance voice | Yann Bean |
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