The process for macOS is straightforward.
The Complete Guide to Uninstalling Ren'Py from Windows, macOS, and Linux uninstall renpy
If you created games, your projects are likely located in a projects folder inside the Ren'Py directory. If you want to keep them, move them elsewhere before deleting the main folder. The process for macOS is straightforward
Right-click the Ren’Py folder > > Security > Advanced > Change owner to your user account. Then delete. and Linux If you created games