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: Unlike the vagina, the rectum does not possess Bartholin's glands or mucosal mechanisms to produce natural lubrication during arousal. External lubrication must always be added manually.

Lubricants with glycerin (may cause burning sensation), parabens, fragrances, flavors, or "tingling" or "warming" effects. Never use numbing lubricants—pain is important feedback telling you to slow down or stop. Anal sex

PrEP prevents HIV only, not other STIs. Condoms provide broader protection. Many people use both PrEP and condoms, or PrEP alone after discussing risks with a provider. : Unlike the vagina, the rectum does not

Place the tip of the penis or toy against the opening. Allow the receptive partner to control the speed, pushing gently down against the object rather than forcing it in. Many people use both PrEP and condoms, or

While the rectum is naturally self-cleaning, many people feel anxious about cleanliness.

The anus and rectum are delicate areas that differ significantly from the vagina in terms of structure and function.